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Applying one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we seek out to unravel the mechanistic elements of the composition and dynamics of chromosomes. Our exploration passions include:
You often get involved in discussions about science and religion. You've got also written various textbooks on the subject. Don’t you feel that at some time We're going to know everything and that God’s position will likely be more than?
[Laughs] ‘It was certainly an excellent threat! At the time, I was well knowledgeable that it could go wrong Which I could develop into a lot less profitable, but I just dismissed that. Curiosity has constantly been my strongest driving power. And fortuitously it all labored out.’
Our get the job done was immediately adopted up by others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 published their conclusions on transistors made from single- and multi-walled carbon nanotubes in Used Physics Letters.
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and initially ever analyze on the dynamics DNA supercoils and the discovery of supercoil hopping
Example (three) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in grey, the rim of your pore is highlighted in crimson, along with a ceesdekker.net 3D rendering of your motion of the DNA rod is exhibited.
Since 2000 he moved to solitary-molecule biophysics and nanobiology, with exploration from DNA supercoiling studies of nucleosomes and DNA fix proteins to DNA translocation as a result of nanopores. Recently his research has focused on studying cell division with bacteria on chip, though his ultimate desire is in the course of recognizing synthetic cells.
Atomic drive microscopy exhibits that vaccinia topoisomerase IB generates filaments on DNA inside of a cooperative fashion
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But carbon nanotubes have remained a research subject matter of sizeable desire to lots of. In truth, the outlook on applying carbon nanotubes to make simple products, in parts for example radio-frequency electronics, digital electronics and flexible electronics, continues to be dazzling.
‘The concept that There may be this kind of thing like a starting, a huge bang, is now an interesting signpost to contemplate that there was a creator. But far more commonly, and on The premise of pure rationality, I also get there in a Christian interpretation of reality. An atheistic worldview is really a naturalistic worldview: fundamentally, you can find only atoms and pure forces that we can measure.
2006, very first demonstration of molecular sorting inside of a lab on a chip making use of biomotors; discovery of nanobubbles in stable-point out nanopores; and initial estimate of electrokinetic Strength conversion in a very nanofluidic channel
Enable’s first look back in the mean time if you chose to change your concentration from superconductivity and nanotubes to biology at the conclusion of the nineteen nineties.
Supercoiling-dependent DNA binding: quantitative modeling and programs to bulk and one-molecule experiments